用低毒力的活溶组织内阿米巴滋养体对仓鼠进行主动免疫。
Active immunization in hamsters with live Entamoeba histolytica trophozoites of low virulence.
作者信息
Tsutsumi V, Shibayama-Salas M, Campos-Rodríguez R, Pacheco-Yépez J, Martínez-Palomo A
机构信息
Departamento de Patología Experimental, Centro de Investigación de Estudios Avanzados del IPN, México, DF, México.
出版信息
Arch Med Res. 1992;23(2):161-3.
Live trophozoites of Entamoeba histolytica of low virulence (LV) were inoculated intraportally in hamsters. One week later they were challenged intrahepatically with highly virulent (HV) trophozoites of the same strain and sacrificed 1 week later. Significant protection manifested by the production of smaller lesions was observed in immunized animals. Antiamebic IgG levels were significantly higher in the immunized group. Histologically, livers of immunized animals presented small lesions containing foamy macrophages, epithelioid cells, fibroblasts and devoid of amebas. Lymphocyte and plasma cell infiltrates were seen periportally.
将低毒力（LV）溶组织内阿米巴的活滋养体经门静脉接种到仓鼠体内。一周后，用同一菌株的高毒力（HV）滋养体对其进行肝内攻击，并在1周后处死。在免疫动物中观察到，通过产生较小的病变表现出显著的保护作用。免疫组的抗阿米巴IgG水平显著更高。组织学上，免疫动物的肝脏呈现出小病变，其中含有泡沫状巨噬细胞、上皮样细胞、成纤维细胞，且无阿米巴。在门静脉周围可见淋巴细胞和浆细胞浸润。
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