甲硝唑治疗实验性阿米巴肝脓肿愈合过程中的组织学变化。
Histological changes during healing of experimental amebic liver abscess treated with metronidazole.
作者信息
Martínez-Gigena M P, Shibayama-Salas M, Tsutsumi V, Martínez-Palomo A
机构信息
Departamento de Patología Experimental, Centro de Investigación y de Estudios Avanzados del IPN, México, DF.
出版信息
Arch Med Res. 1992;23(2):209-12.
Morphological changes during the healing of amebic liver abscess (ALA) in hamsters treated with metronidazole were studied. Animals with ALA of 4 days of evolution were treated orally with metronidazole (5 mg/100 g for 10 days). Liver samples were studied at different times from the beginning of treatment up to 22 days. The resolution of ALA was accompanied by chronic inflammatory reaction, increased number of foamy macrophages and gradual disappearance of the granulomas. Neoformed hepatocytes and blood vessels, and proliferation of biliary ducts were also observed. Foamy macrophages play an important role in the adequate healing of ALA.
研究了用甲硝唑治疗的仓鼠阿米巴肝脓肿（ALA）愈合过程中的形态学变化。将病程为4天的ALA动物口服甲硝唑（5mg/100g，持续10天）。从治疗开始到22天的不同时间对肝脏样本进行研究。ALA的消退伴随着慢性炎症反应、泡沫状巨噬细胞数量增加和肉芽肿逐渐消失。还观察到新生肝细胞和血管以及胆管增生。泡沫状巨噬细胞在ALA的充分愈合中起重要作用。
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