抗溶组织内阿米巴66 kDa表面抗原单克隆抗体对黏附的抑制作用
Inhibition of adhesion by monoclonal antibody to 66 kDa surface antigen of Entamoeba histolytica.
作者信息
Vohra H, Kaur S, Ganguly N K, Mahajan R C
机构信息
Department of Parasitology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
Arch Med Res. 1992;23(2):235-7.
The adherence of E. histolytica trophozoites to target cells was studied using a monoclonal antibody to a major surface antigen of 66 kDa. Preincubation of trophozoites with monoclonal antibody decreased their ability to adhere to and engulf erythrocytes and destruction of CHO cells. The monoclonal antibody was specific for the 66 kDa antigen which is possibly a major participant in adhesion which precedes other events in phagocytosis and cytopathic effects.
利用针对66 kDa主要表面抗原的单克隆抗体研究了溶组织内阿米巴滋养体对靶细胞的黏附情况。将滋养体与单克隆抗体预孵育会降低其黏附并吞噬红细胞以及破坏CHO细胞的能力。该单克隆抗体对66 kDa抗原具有特异性，该抗原可能是吞噬作用和细胞病变效应中先于其他事件的黏附过程的主要参与者。
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