抗溶组织内阿米巴66kD表面抗原单克隆抗体对靶细胞黏附的抑制作用
Inhibition of target cell adhesion by monoclonal antibody to the 66 kD surface antigen of Entamoeba histolytica.
作者信息
Vohra H, Kaur S, Wangoo A, Ganguly N K, Mahajan R C
机构信息
Dept. of Parasitology, Postgraduate Institute of Medical Education and Research, PGIMER, Chandigarh, India.
出版信息
Infection. 1992 Sep-Oct;20(5):279-82. doi: 10.1007/BF01710795.
The adherence of Entamoeba histolytica trophozoites to target cells was studied using a monoclonal antibody to a major surface antigen of 66 kD. Preincubation of trophozoites with monoclonal antibody decreased their ability to adhere to and engulf erythrocytes and to destroy Chinese hamster ovary cells. The monoclonal antibody was specific for the 66 kD antigen, which is possibly a major participant in the adhesion that precedes phagocytosis and cytopathic effects.
利用针对66kD主要表面抗原的单克隆抗体，研究了溶组织内阿米巴滋养体对靶细胞的黏附情况。用单克隆抗体对滋养体进行预孵育，会降低其黏附并吞噬红细胞以及破坏中国仓鼠卵巢细胞的能力。该单克隆抗体对66kD抗原具有特异性，而66kD抗原可能是吞噬作用和细胞病变效应之前黏附过程中的主要参与者。
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