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Molecular properties of the sodium channel: a receptor for multiple neurotoxins.

作者信息

Catterall W A, Trainer V, Baden D G

机构信息

Department of Pharmacology, University of Washington, Seattle 98195.

出版信息

Bull Soc Pathol Exot. 1992;85(5 Pt 2):481-5.

PMID:1340350
Abstract

Sodium channels are the receptors for more than 10 distinct classes of biological toxins which act at five or more receptor sites. Brevetoxins and ciguatoxins act at neurotoxin receptor site 5. This receptor site is located on the alpha subunit of the sodium channel, and peptide segments in domain IV of that subunit are important in brevetoxin binding.

摘要

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