尼日利亚学童中乙胺嘧啶对疟疾的抑制作用。

Suppression of malaria with pyrimethamine in Nigerian schoolchildren.

作者信息

ARCHIBALD H M, BRUCE-CHWATT L J

出版信息

Bull World Health Organ. 1956;15(3-5):775-84.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2538299/

Abstract

The authors describe a two-year investigation carried out on a group of Nigerian schoolchildren with the object of assessing the effect of suppressing malaria infection with pyrimethamine on the physical development of the African child. The results showed that the average gain in weight of the treated children over the period of the investigation was significantly greater than that of the untreated children. Despite the relatively high weekly dose of the drug no side-effects were observed, and no alarming manifestation of malaria was noted when administration of the drug was discontinued.

摘要

作者描述了一项针对一群尼日利亚学童进行的为期两年的调查，目的是评估用乙胺嘧啶抑制疟疾感染对非洲儿童身体发育的影响。结果显示，在调查期间，接受治疗的儿童的平均体重增加明显高于未接受治疗的儿童。尽管该药物的每周剂量相对较高，但未观察到副作用，并且在停药后也未发现疟疾的惊人表现。

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