Muniz-Junqueira M I, Moraes M A, Marsden P D
Departamento de Pediatria, Faculdade de Ciências da Saúde, Universidade de Brasilia, DF, Brasil.
Rev Soc Bras Med Trop. 1992 Oct-Dec;25(4):257-9. doi: 10.1590/s0037-86821992000400008.
We report the clinical picture, treatment and evolution of a child with hyperreactive malarious splenomegaly treated outside the endemic area of malaria. The patient presented gross splenomegaly, proceeded from an area where malaria is endemic, showed increased immunoglobulins levels, high antimalarial antibody titres and hepatic sinusoidal lymphocytosis. The child did not return to an area where malaria is endemic and showed a favorable response to only one course of quinine. The response of this patient to limited antimalarial therapy suggests the importance of reinfection with malaria in the development and maintenance of this syndrome.
我们报告了一名在疟疾流行区以外接受治疗的患有高反应性疟疾性脾肿大儿童的临床表现、治疗及病情演变。该患者出现巨脾，来自疟疾流行地区，免疫球蛋白水平升高、抗疟抗体滴度高且肝窦淋巴细胞增多。该儿童未返回疟疾流行地区，仅接受一个疗程的奎宁治疗便显示出良好反应。该患者对有限的抗疟治疗的反应表明，疟疾再感染在该综合征的发生和维持中具有重要作用。
