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[克罗恩病和溃疡性结肠炎活动度的诊断:锝-99m葡庚糖酸盐标记白细胞闪烁扫描术]

[Diagnosis of activity in Crohn's disease and ulcerative colitis: scintigraphy with TC-99m glucoheptonate labelled leukocytes].

作者信息

Orellana P, Ríos L, Gajardo P, Olea E, Oritz V, Nagel J, Quintana C, Gil M C

机构信息

Departamento de Radiología, Facultad de Medicina, Pontificia Universidad Católica de Chile.

出版信息

Rev Med Chil. 1992 Sep;120(9):1006-10.

PMID:1340976
Abstract

We evaluated a pre-tinning leukocyte labeling technique using Glucoheptonate-Sn lyophilized kit, in the detection of activity in 15 patients with clinical and laboratory signs of active inflammatory bowel disease (IBD). 25 patients, without gastrointestinal disease were the control group. In 7/8 patients with Crohn's disease and in 7/7 with Ulcerative Colitis the study was positive. The negative study corresponded to a patient who has only involvement of the duodenum, an area of difficult evaluation due to the high liver uptake. 3/25 patients of the control group had activity in the intestine at 4 hour images. In spite of the small group evaluated, we believe that this labeling technique is a promising procedure for evaluation of activity in patients with IBD (Sensitivity 93.3%, Specificity 88.0%).

摘要

我们使用葡庚糖酸锡冻干试剂盒评估了一种预镀锡白细胞标记技术,用于检测15例有活动性炎症性肠病(IBD)临床和实验室体征患者的活性。25例无胃肠道疾病的患者作为对照组。在8例克罗恩病患者中的7例以及7例溃疡性结肠炎患者中的7例中,该研究呈阳性。阴性研究结果对应的是一名仅十二指肠受累的患者,由于肝脏摄取率高,该区域难以评估。对照组的25例患者中有3例在4小时图像时肠道有活性。尽管评估的样本量较小,但我们认为这种标记技术是评估IBD患者活性的一种有前景的方法(敏感性93.3%,特异性88.0%)。

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