Ogata A J, Camano L, Brunoni D
Discipline of Obstetrics, Escola Paulista de Medicina, São Paulo, Brasil.
Rev Paul Med. 1992 Jul-Aug;110(4):147-51.
The objective of the present study was to determine the presence of risk factors for the occurrence of neural tube defects. Data for 33,535 births which occurred at Hospital do Servidor Público Estadual de São Paulo from July 1973 to December 1986 were collected in a prospective manner as recommended by "Estudo Colaborativo Latino-Americano de Malformações Congênitas" (ECLAMC, Collaborative Latin American Study on Congenital Malformations). Twenty-six cases of neural tube defects were detected (0.77/1000 births). Of these, 11 were cases of spina bifida (0.39/1000 births), 9 of anencephaly (0.27/1000 births) and 6 of encephalocele (0.18/1000 births). We observed a higher frequency of polyhydramnios, premature labor, Apgar scores of less than 7 at the first and fifth minutes, low birth weight and intrauterine growth retardation.
本研究的目的是确定神经管缺陷发生的风险因素。按照“拉丁美洲先天性畸形协作研究”（ECLAMC）的建议，前瞻性收集了1973年7月至1986年12月在圣保罗州立公立医院出生的33535例婴儿的数据。共检测到26例神经管缺陷（0.77/1000例出生）。其中，11例为脊柱裂（0.39/1000例出生），9例为无脑儿（0.27/1000例出生），6例为脑膨出（0.18/1000例出生）。我们观察到羊水过多、早产、出生后第1分钟和第5分钟阿氏评分低于7分、低出生体重和宫内生长迟缓的发生率较高。
