Schmitt F C, Andrade L M, de Lucca L A
Departament of Pathology, Faculdade de Medicina de Botucatu, UNESP, SP, Brasil.
Rev Paul Med. 1992 Jul-Aug;110(4):158-62.
The authors studied the expression of estrogen receptor (ER) in tissues of breast carcinomas which were previously fixed in formalin and paraffin-embedded. The ER expression was correlated with several histological findings, namely grade of differentiation, tumor necrosis, desmoplasia, lymphocytic infiltration and elastosis. The ER was detected in tissues using the avidin-biotin immunoperoxidase technique associated with the H222 monoclonal antibody from Abbott. All 39 biopsies were of infiltrating ductal carcinoma of breast and 16 of them expressed ER. The statistical analysis showed that the expression of ER was correlated with histological findings of good prognosis as well differentiated carcinomas, no tumor necrosis, absence or mild lymphocytic infiltration around the tumor cells and severe elastosis.
作者研究了雌激素受体（ER）在先前用福尔马林固定并石蜡包埋的乳腺癌组织中的表达。ER表达与若干组织学结果相关，即分化程度、肿瘤坏死、促结缔组织增生、淋巴细胞浸润和弹性组织变性。使用与雅培公司的H222单克隆抗体相关的抗生物素蛋白-生物素免疫过氧化物酶技术在组织中检测ER。所有39份活检标本均为乳腺浸润性导管癌，其中16份表达ER。统计分析表明，ER的表达与预后良好的组织学结果相关，如高分化癌、无肿瘤坏死、肿瘤细胞周围无或轻度淋巴细胞浸润以及严重弹性组织变性。
