Von Rosen A, Linder S, Harmenberg U, Wiechel K L
Department of Surgery, Karolinska Hospital, Stockholm, Sweden.
Surg Oncol. 1992 Apr;1(2):109-13. doi: 10.1016/0960-7404(92)90023-e.
Serum levels of the tumour antigens CA 19-9 and CA-50 and their relation to the extent of the disease were studied in 97 patients with carcinoma of the pancreas. Of 13 patients with normal serum concentrations of CA 19-9, 11 (84.6%) had irresectable disease, whereas 87.5% of the patients with resectable disease expressed antigen levels above cut-off. Following attempted radical surgery, preoperatively elevated serum levels decreased in eight patients (50%). Unchanged and high levels were associated with residual disease and early death. Clinical signs of recurrence were preceded by elevated serum levels of both tumour antigens.
对97例胰腺癌患者的血清肿瘤抗原CA 19-9和CA-50水平及其与疾病程度的关系进行了研究。在13例血清CA 19-9浓度正常的患者中，11例（84.6%）患有无法切除的疾病，而可切除疾病患者中有87.5%的抗原水平高于临界值。在尝试进行根治性手术后，8例患者（50%）术前升高的血清水平下降。水平未变和高水平与残留疾病和早期死亡相关。两种肿瘤抗原的血清水平升高先于复发的临床体征出现。
