Haun M, Pereira M F, Hoffmann M E, Joyas A, Campos V, Filardi L D, de Castro S L, Duran N
Departamento de Bioquímica, Instituto de Biología, Universidade Estadual de Campinas, S. P., Brazil.
Biol Res. 1992;25(1):21-5.
The biosynthetic pigment from Chromobacterium violaceum BB-78, 1,3-dihydro-2H-indol-2-one and its derivatives exhibit biological activities such as antimicrobial action, low hemolytic effects on red blood cells and in vitro trypanocide activity. A relatively high cytotoxicity on V-79 hamster fibroblast cells of the biosynthetic pigment was found, although with the methylol derivative the toxicity was almost eliminated. The methylol derivative exhibited similar toxicity as Nifurtimox, a known, commercial trypanocide compound.
来自紫色杆菌BB - 78的生物合成色素1,3 - 二氢 - 2H - 吲哚 - 2 - 酮及其衍生物具有生物活性，如抗菌作用、对红细胞的低溶血作用和体外杀锥虫活性。发现该生物合成色素对V - 79仓鼠成纤维细胞具有相对较高的细胞毒性，不过羟甲基衍生物的毒性几乎消除。羟甲基衍生物表现出与已知的商用杀锥虫化合物硝呋替莫相似的毒性。
