Sei Y, Skolnick P, Arora P K
Laboratory of Neuroscience, NIDDK, National Institutes of Health, Bethesda, MD 20892.
Int J Neurosci. 1992 Jul-Aug;65(1-4):247-58. doi: 10.3109/00207459209003298.
Strain differences in both immune function and behavior were observed following exposure of mice to the death of cage-cohorts. AKR/J, BALB/cN, and C3H/HeJ mice were exposed to a dead cohort for two hours at 48 hour intervals for 30 days. During this two hour period, AKR/J mice displayed intense fighting and mounting behavior. In addition, these mice attacked, cannibalized, and buried carcasses. Neither C3H/HeJ nor BALB/cN mice exhibited the complete repertoire of behaviors directed at either carcasses or cage-cohorts observed in AKR/J mice. After 15 exposures to the death of cage-cohorts, allogeneic cytotoxic T-lymphocyte (CTL) response was suppressed in AKR/J mice, but was enhanced or unchanged in C3H/HeJ and BALB/cN mice, respectively. Other immune parameters including natural killer (NK) cell activity, and lipopolysaccharide-stimulated B cell proliferation were unchanged in AKR/J mice but increased in BALB/cN mice exposed to the death of cage-cohorts for thirty days. These results suggest: 1) that both suppression of the CTL response and behaviors indicative of defensive burying in AKR/J mice may specifically be due to the loss of cage-cohorts, since they were not observed following exposure of these mice to the death of contraspecific animals; and 2) that both the behavioral repertoire and immune responses following exposure to the death of cage-cohorts may be strain dependent. This strain dependence may reflect differences in the ability to cope with the intermittent presentation of a stressor, and may explain, at least in part, variability in stress-induced changes in immune functions.
将小鼠暴露于同笼伙伴死亡的环境后，观察到其免疫功能和行为存在品系差异。将AKR/J、BALB/cN和C3H/HeJ小鼠每隔48小时暴露于死亡的同笼伙伴环境中2小时，持续30天。在这2小时期间，AKR/J小鼠表现出强烈的打斗和骑跨行为。此外，这些小鼠还会攻击、同类相食并掩埋尸体。C3H/HeJ和BALB/cN小鼠均未表现出AKR/J小鼠针对尸体或同笼伙伴所观察到的全部行为。在15次暴露于同笼伙伴死亡的环境后，AKR/J小鼠的同种异体细胞毒性T淋巴细胞（CTL）反应受到抑制，但C3H/HeJ和BALB/cN小鼠的CTL反应分别增强或未改变。其他免疫参数，包括自然杀伤（NK）细胞活性和脂多糖刺激的B细胞增殖，在AKR/J小鼠中未发生变化，但在暴露于同笼伙伴死亡环境30天的BALB/cN小鼠中有所增加。这些结果表明：1）AKR/J小鼠中CTL反应的抑制和防御性掩埋行为可能具体是由于同笼伙伴的丧失，因为在将这些小鼠暴露于同种动物死亡的环境后未观察到这些现象；2）暴露于同笼伙伴死亡环境后的行为表现和免疫反应可能具有品系依赖性。这种品系依赖性可能反映了应对应激源间歇性出现的能力差异，并且至少可以部分解释应激诱导的免疫功能变化的变异性。
