Karduck A, Richter H G
Laryngol Rhinol Otol (Stuttg). 1976 Feb;55(2):144-51.
In animals the endolaryngeal application of laser rays of the Nd: YAG Laser MediLas (lambda = 1.06 mum) was tested under microsurgical conditions, the early and late alterations of the vocal cords caused by a dosage of 17 watt/mm2 fractioned over 7 sec were endoscopically observed and studied by light- and electronmicroscopy. A circumscribed vocal cord edema induced by laser entails no functional impairment whatsoever. Histologically the laser lesions can be interpreted as epithelial defect with a reactive inflammation of the adjacent connective tissue. A fundamental loss in substance cannot be realized. The superficial defect healed within 18 days; after 7 weeks the zone of regeneration and the undamaged part of the vocal cord could no longer be differentiated neither by light- nor by electronmicroscopy. Laser surgery has the special merit of permitting a touchless and bloodless operation. These experiences with the Nd: YAG Laser MediLas encourage us to use this procedure in clinical tests for the therapy of benignant squamous epithelium hyperplasia of vocal cords.
在动物身上,在显微手术条件下测试了Nd:YAG激光MediLas(波长λ = 1.06μm)的喉内激光应用,通过内镜观察并借助光镜和电镜研究了在7秒内以17瓦/平方毫米的剂量对声带造成的早期和晚期改变。激光引起的局限性声带水肿未造成任何功能损害。从组织学上看,激光损伤可解释为上皮缺损伴相邻结缔组织的反应性炎症。未出现实质性的根本损失。表面缺损在18天内愈合;7周后,无论是光镜还是电镜都无法再区分声带的再生区域和未受损部分。激光手术具有允许进行非接触式和无血手术的特殊优点。这些关于Nd:YAG激光MediLas的经验鼓励我们在声带良性鳞状上皮增生治疗的临床试验中使用该方法。