Miller G J
MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middlesex, UK.
Ann Epidemiol. 1992 Jul;2(4):387-91. doi: 10.1016/1047-2797(92)90087-7.
High levels of factor VII coagulant activity (VIIc) and fibrinogen concentration are independently associated with an increased risk of acute coronary heart disease in middle-aged men. Studies have, therefore, been undertaken to determine the responsiveness of these hemostatic factors to changes in diet and smoking habit. Plasma VIIc increases acutely with an increase in total fat intake, but fibrinogen is unaffected. In the general community, men who have a high total fat intake for their body size tend to have a high VIIc level. Changes in the dietary ratio of saturated to polyunsaturated fat of up to 14 days' duration have no effect on factor VIIc or fibrinogen (there are conflicting reports on the influence of dietary very-long-chain polyunsaturated fatty acids on fibrinogen concentration). Cigarette smokers have a higher fibrinogen concentration than do nonsmokers, but their levels slowly revert toward those of nonsmokers when the habit is relinquished.
高水平的凝血因子VII促凝活性（VIIc）和纤维蛋白原浓度与中年男性急性冠心病风险增加独立相关。因此，人们开展了研究以确定这些止血因子对饮食和吸烟习惯变化的反应性。血浆VIIc会随着总脂肪摄入量的增加而急剧升高，但纤维蛋白原不受影响。在普通人群中，按体型计算总脂肪摄入量高的男性往往VIIc水平也高。持续长达14天的饱和脂肪与多不饱和脂肪饮食比例变化对因子VIIc或纤维蛋白原没有影响（关于饮食中极长链多不饱和脂肪酸对纤维蛋白原浓度的影响存在相互矛盾的报道）。吸烟者的纤维蛋白原浓度高于不吸烟者，但当戒烟后，他们的水平会慢慢恢复到不吸烟者的水平。
