Sharrett A R
Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
Ann Epidemiol. 1992 Jul;2(4):467-9. doi: 10.1016/1047-2797(92)90096-9.
The Atherosclerosis Risk in Communities (ARIC) Study is an observational epidemiologic study conducted in four communities. ARIC has two major components: One records the occurrence of myocardial infarction resulting in hospitalization and coronary heart disease death in adults aged 35 to 74 living in the communities; the other is a prospective study of representative cohorts aged 45 to 64. Measurement of hemostatic factors is part of the cohort study, whose major objectives include investigating etiologic factors associated with atherosclerosis and its clinical outcomes. Arterial intimal-medial wall thickness, an index of early atherosclerosis, is measured precisely from ultrasound images of carotid and popliteal arteries. Participants (n = 15,801) completed their first examination, which included measurements of factors associated with coagulation (fibrinogen, factor VII, factor VIII, and von Willebrand factor) and coagulation inhibition (protein C and antithrombin III). Measures of coagulation activation, platelet activation, and fibrinolytic activity will be performed on stored plasma from selected case patients and control subjects.
社区动脉粥样硬化风险（ARIC）研究是一项在四个社区开展的观察性流行病学研究。ARIC有两个主要部分：一是记录居住在这些社区的35至74岁成年人中因心肌梗死住院及冠心病死亡的发生情况；另一个是对45至64岁代表性队列的前瞻性研究。止血因子的测量是该队列研究的一部分，其主要目标包括调查与动脉粥样硬化及其临床结局相关的病因因素。动脉内膜中层厚度是早期动脉粥样硬化的一个指标，通过颈动脉和腘动脉的超声图像精确测量。参与者（n = 15,801）完成了首次检查，其中包括测量与凝血相关的因子（纤维蛋白原、因子VII、因子VIII和血管性血友病因子）以及凝血抑制因子（蛋白C和抗凝血酶III）。将对选定病例患者和对照受试者的储存血浆进行凝血激活、血小板激活和纤溶活性的检测。
