Ciprandi G, Buscaglia S, Tosca M, Canonica G W
Department of Internal Medicine, University of Genoa, Italy.
J Investig Allergol Clin Immunol. 1992 Jan-Feb;2(1):15-8.
The pharmacological treatment of allergic conjunctivitis includes the use of topical antiinflammatory drugs, i.e. steroids and NSAIDs (nonsteroidal antiinflammatory drugs), such as acetylsalicylic acid (ASA). However, steroids are not suitable in prolonged treatment, as well as in pollinosis in the Mediterranean area, because of their side effects. The present double-blind study evaluates the topical use of acetylsalicylic acid eye drops (1% solution) compared to placebo in the treatment of patients with seasonal allergic conjunctivitis during the period June-July 1990. The patients were randomized and treated with ASA eye drops or placebo eye drops, both applied as one drop in each eye q.i.d. for 14 days. The severity of symptoms was evaluated before and after treatment by the investigator and the patient. An overall judgement of therapeutic response was expressed independently by the patient and the investigator at the end of the treatment. The ASA-treated group improved significantly compared to the placebo-treated group. No serious side effects were observed. The results confirm the clinical efficacy and safety of topical ASA in the treatment of pollen-induced allergic conjunctivitis.
过敏性结膜炎的药物治疗包括使用局部抗炎药，即类固醇和非甾体抗炎药（NSAIDs），如乙酰水杨酸（ASA）。然而，由于类固醇的副作用，它们不适用于长期治疗以及地中海地区的花粉症。本双盲研究评估了1990年6月至7月期间，与安慰剂相比，局部使用乙酰水杨酸滴眼液（1%溶液）治疗季节性过敏性结膜炎患者的效果。患者被随机分组，分别用ASA滴眼液或安慰剂滴眼液治疗，每只眼睛每日滴入一滴，共14天。治疗前后，研究者和患者对症状的严重程度进行了评估。治疗结束时，患者和研究者分别独立给出了对治疗反应的总体判断。与安慰剂治疗组相比，ASA治疗组有显著改善。未观察到严重的副作用。结果证实了局部使用ASA治疗花粉引起的过敏性结膜炎的临床疗效和安全性。
