Balsalobre B, Hernández-Godoy J, Planelles D
Department of Clinical Biopathology, Hospital La Fe, Valencia, Spain.
J Investig Allergol Clin Immunol. 1992 Mar-Apr;2(2):91-5.
The presence of autoantibodies was examined in 100 adult patients splenectomized because of abdominal trauma and without systemic disease, and the results were compared with those observed in a healthy control group. Thirty-seven percent of the patients studied presented some type of autoantibody. Those observed were antinuclear, anti-smooth muscle and, in 1 case, anti-reticulin. Patients with antinuclear antibodies have no antibodies against native DNA, but in 5 cases, anti-Ro (SS-A) and anti-La (SS-B) antibodies were observed. Rheumatoid factors were also found, but their incidence was similar in patients and controls. The incidence of autoantibodies proved not to be related to either the period of time since splenectomy or to age of the patient; they were observed in patients many years after splenectomy and in individuals of both sexes and all ages. Although the presence of autoantibodies seemed to have no effect on our patients, all of whom were asymptomatic, it is important to be aware of this phenomenon when evaluating the laboratory results obtained from splenectomized patients.
对100例因腹部创伤行脾切除术且无全身性疾病的成年患者检测自身抗体，并将结果与健康对照组进行比较。研究的患者中有37%出现了某种类型的自身抗体。检测到的自身抗体有抗核抗体、抗平滑肌抗体，1例患者出现抗网硬蛋白抗体。有抗核抗体的患者没有针对天然DNA的抗体，但有5例患者检测到抗Ro（SS - A）和抗La（SS - B）抗体。还发现了类风湿因子，但其在患者和对照组中的发生率相似。自身抗体的发生率被证明与脾切除术后的时间或患者年龄均无关；在脾切除术后多年的患者以及各年龄段和性别的个体中均观察到自身抗体。尽管自身抗体的存在似乎对我们所有无症状的患者没有影响，但在评估脾切除患者的实验室检查结果时，了解这一现象很重要。
