急性过敏性肺炎患者血清及支气管肺泡灌洗液中的类风湿因子活性。

Rheumatoid factor activity in serum and bronchoalveolar lavage fluid from patients with acute hypersensitivity pneumonitis.

作者信息

Martínez-Cordero E, Negrete-García M C, Mendoza A

机构信息

Research Unit, National Institute of Respiratory Diseases (INER), Hospital 20 de Noviembre, ISSSTE, Mexico.

出版信息

J Investig Allergol Clin Immunol. 1992 Sep-Oct;2(5):254-7.

PMID:1342907

Abstract

The presence of rheumatoid factor was detected in both serum and bronchoalveolar lavage fluid (BALF) from patients with acute pigeon breeder's disease. IgM rheumatoid factor was positive in 14 of 20 serum samples and 6 of 20 BALF samples by ELISA. In contrast, negative results were found in 20 healthy subjects with a history of avian antigen exposure, as well as in the serum and BALF from 10 normal subjects. The simultaneous presence of rheumatoid factor in serum and BALF occurred in five patients, and four of them revealed high levels of rheumatoid factor in BALF in comparison with serum determinations. These abnormalities may play an important role during the acute inflammatory reaction in hypersensitivity pneumonitis.

摘要

在患有急性养鸽者病的患者的血清和支气管肺泡灌洗液（BALF）中均检测到类风湿因子的存在。通过酶联免疫吸附测定法（ELISA），20份血清样本中有14份IgM类风湿因子呈阳性，20份BALF样本中有6份呈阳性。相比之下，20名有禽类抗原接触史的健康受试者以及10名正常受试者的血清和BALF检测结果均为阴性。五名患者的血清和BALF中同时存在类风湿因子，其中四名患者的BALF中类风湿因子水平高于血清检测结果。这些异常可能在超敏性肺炎的急性炎症反应中起重要作用。