Słodowska-Hajduk Z
Miedzywydziałowej Katedry Patofizjologii, Akademii Medycznej im. M. Kopernika, Krakowie.
Folia Med Cracov. 1992;33(1-4):73-83.
The aim of these tests was to show whether in an experimental diabetes toxic compounds of the cadmium and lead would intensify changes in the enzymes activity caused by a diabetes itself. The test was carried out on the Wistar breed of rats. After inducing the experimental diabetes animals were given cadmium and lead compounds by searchers directly into their stomachs. The following enzymes the AspAT and the AlAT and the alkaline phosphatase (AP) were indicated among all tested animals. The statistic significant increase of the AspAT and the AlAT and the decrease of the alkaline phosphatase in a blood were documented in the experimental diabetes as well as among animals subjected to the cadmium and lead in comparison with the results secured from the checking group of animals. In comparison to animals with a diabetes itself, in the experimental diabetes the toxic compounds of the cadmium and lead explicitly increased the activity changes of the AlAT and the alkaline phosphatase. On the grounds of the above results it can be assumed that in the diabetic diseases the toxic metals may intensify pathological changes.
这些测试的目的是表明，在实验性糖尿病中，镉和铅的有毒化合物是否会加剧糖尿病本身所引起的酶活性变化。该测试在Wistar品系大鼠身上进行。诱发实验性糖尿病后，研究人员将镉和铅化合物直接灌入动物胃中。在所有受试动物中，检测了以下几种酶：天冬氨酸氨基转移酶（AspAT）、丙氨酸氨基转移酶（AlAT）和碱性磷酸酶（AP）。与对照组动物的结果相比，实验性糖尿病动物以及接触镉和铅的动物血液中AspAT和AlAT显著增加，碱性磷酸酶降低。与仅患有糖尿病的动物相比，在实验性糖尿病中，镉和铅的有毒化合物明显加剧了AlAT和碱性磷酸酶的活性变化。基于上述结果，可以假定在糖尿病疾病中，有毒金属可能会加剧病理变化。
