Kanić M, Sepcić J
Neurologische Klinik, Universitätspital, Zürich, Schweiz.
Lijec Vjesn. 1992 May-Aug;114(5-8):134-6.
In a group of 292 patients, clinically definite cases of multiple sclerosis, 91 of them were administered Tetracosactrin (Synacthen Depot) during the initial or exacerbation attack of the disease. Two female patients developed typical anaphylaxis during the drug use: the first patient after the twenty-second injection and the second one after the sixth injection. Negativity of the cutaneous test to zinc oxide in these two female patients, increased IgE immunoglobulin concentration and positive RAST to the drug suggested to the feature of immediate allergy conditioned by reagins.
在一组292例临床确诊为多发性硬化症的患者中，其中91例在疾病初始发作或病情加重期使用了二十四肽促皮质素（长效合成促皮质素）。两名女性患者在用药期间出现了典型的过敏反应：第一名患者在第22次注射后，第二名患者在第6次注射后。这两名女性患者对氧化锌皮肤试验呈阴性、免疫球蛋白IgE浓度升高以及对该药物的放射性变应原吸附试验呈阳性，提示为由反应素引起的速发型过敏特征。
