Vrhovac B, Vrhovac R
Zavod za klinicku farmakologiju Klinike za unutrasnje bolesti s poliklinikom KBC, Medicinski fakultet Zagreb.
Lijec Vjesn. 1992 Sep-Dec;114(9-12):275-84.
Principal changes in the drug field in this country in 1991 were caused by the armed aggression committed against Croatia and the succession of disturbances that this aggression induced. Abroad as many as 13.6% of drugs could be ranked as category A. Here dominate some drugs for AIDS, which is a significant problem in medicine, but also some drugs for rare diseases ("orphan drugs"), like Gaucher's disease, precocious puberty etc. In this country (until the sovereignty was reached on October 8, 1991) 13.8% of drugs belonging to category B were approved. In category C ranked were 83.0% of drugs, abroad 75%. Two in this country (rutoside and creatinephosphate), one abroad (ditiocarb) were classed in category D. At preparing new Drug Law of independent Croatia, caution is necessary over numerous details which will enable us to become, in this field too, as soon as possible a part of the developed Europe. The latest List of Drugs that is paid by the Croatian Health Insurance is discussed. It comprises up to 230 generic names, excluding those that are--unjustifiably--most prescribed. The List's aim is to rationalize drug therapy, allowing other modes of prescribing improvement. To a large degree drug prescribing is not rational. The latest data (1990) have shown that only 4 out of 10 most prescribed drugs in Zagreb are undoubtedly efficacious, 9 out of 10 in Ljubljana, 5 out of 10 (1989/90) in former Yugoslavia, and abroad ("in the world") all 10. The characteristics of drug filed in war are reviewed as well as problems connected with drug donations. The importance of concern that "aimed" donations replace those that are not optimally used is stressed. The article ends with the question of the importance of objective information sources in drug field.
1991年该国药品领域的主要变化是由针对克罗地亚的武装侵略以及此次侵略引发的一系列骚乱所致。在国外，多达13.6%的药品可列为A类。这里，治疗艾滋病的一些药品占主导地位，艾滋病在医学上是一个重大问题，同时还有一些治疗罕见疾病（“孤儿药”）的药品，如高雪氏病、性早熟等。在该国（直到1991年10月8日恢复主权），13.8%属于B类的药品获得批准。C类药品占83.0%，在国外占75%。该国两种药品（芦丁和磷酸肌酸）、国外一种药品（二硫卡钠）被列为D类。在制定独立克罗地亚的新药品法时，对于众多细节必须谨慎，这将使我们能够在这个领域尽快成为发达欧洲的一部分。讨论了克罗地亚健康保险支付的最新药品清单。它包含多达230个通用名，不包括那些不合理地被大量处方的药品。该清单的目的是使药物治疗合理化，允许改进其他处方方式。很大程度上，药物处方并不合理。最新数据（1990年）表明，在萨格勒布最常处方的10种药物中只有4种无疑有效，在卢布尔雅那10种中有9种，在前南斯拉夫10种中有5种（1989/90年），而在国外（“世界范围内”）10种都有效。回顾了战争时期药品领域的特点以及与药品捐赠相关的问题。强调了关注“有针对性的”捐赠取代未得到最佳利用的捐赠的重要性。文章最后提出了药品领域客观信息来源重要性的问题。
