Prigent Y
Unité de Soins aux Etats Dysthymiques, Hôtel-Dieu, Pont L'Abbé.
Ann Med Psychol (Paris). 1992 Apr-May;150(4-5):359-62.
From the results of an 8 years naturalistic and pragmatical study in a Care Unit for Patients with Dysthymic Disorders at Hôtel-Dieu-Pont-L'Abbé (France), the author points out that there is during long term antidepressive therapies a facilitating action in the psychoaffective elaboration and maturation. The author stresses the importance of agonistic molecules in the serotonin which seem to favour a psychological "working-through" probably because of the lifting of compulsive-obsessive mechanisms present in chronic an residual depressions. The authors underlines the importance of naturalistic and pragmatical studies as an alternative or as a complement to protocolar and controlled studies which are often biased. These biases are increased because of complicated psychometrics and by recent legal measures which tend to lessen the clinical credibility of these "controlled" studies.
根据在法国阿贝桥迪厄医院心境恶劣障碍患者护理单元进行的一项为期8年的自然主义和实用性研究结果，作者指出，在长期抗抑郁治疗过程中，对心理情感的细化和成熟有促进作用。作者强调血清素中激动分子的重要性，这些分子似乎有利于心理上的“彻底解决”，这可能是因为慢性和残留性抑郁症中存在的强迫-强迫机制得到缓解。作者强调自然主义和实用性研究作为对往往有偏差的标准化和对照研究的替代或补充的重要性。由于复杂的心理测量学以及最近倾向于降低这些“对照”研究临床可信度的法律措施，这些偏差有所增加。
