Gutnisky A, Rizzo N, Castro M E, Garbossa G
Centro de Estudios Farmacológicos y Botánicos, Buenos Aires, Argentina.
Acta Physiol Pharmacol Ther Latinoam. 1992;42(3):139-46.
The polyphenols are part of the composition of many foods, it is known the inhibitory effect of tea and coffee through the tannins on iron intestinal absorption; the "yerba mate" (Ilex Paraguarensis) is a beverage widely used in South America, that has a high content of a polyphenol named chlorogenic acid. The present work shows the effect of this substance in nonhem iron absorption. An intestinal loop, was made in rats, to form a closed cavity in a small section of intestine tieing it from the pilorous to a distance of six cm. In this closed cavity a solution of 59Fe was injected with different doses of chlorogenic acid; it was living 20, 40 and 120 minutes into the loop, and after this different times, the blood, spleen, liver, femur and intestine were removed to measure the 59Fe uptake to be compared with the control group. The results gave an intense inhibitory effect on the intestinal iron absorption with doses of 0.58 and 1.7 mM per rat of chlorogenic acid at the different times studied.
多酚是许多食物成分的一部分，已知茶和咖啡中的单宁对铁的肠道吸收有抑制作用；“马黛茶”（巴拉圭冬青）是南美广泛使用的一种饮料，其含有高含量的一种名为绿原酸的多酚。本研究展示了该物质对非血红素铁吸收的影响。在大鼠身上制作肠袢，在小肠的一小段形成一个封闭腔，从幽门处结扎至6厘米的距离。在这个封闭腔内注射含有不同剂量绿原酸的59Fe溶液；在肠袢内存活20、40和120分钟，在这些不同时间过后，取出血液、脾脏、肝脏、股骨和肠道以测量59Fe的摄取量，并与对照组进行比较。结果表明，在研究的不同时间，每只大鼠给予0.58和1.7 mM剂量的绿原酸对肠道铁吸收有强烈的抑制作用。
