分歧巴贝斯虫疫苗

Babesia divergens vaccine.

作者信息

Gorenflot A, Precigout E, Valentin A, Bissuel G, Carcy B, Brasseur P, Moreau Y, Schrevel J

机构信息

Laboratoire de Biologie Cellulaire, Faculté de Pharmacie, Montpellier, France.

出版信息

Mem Inst Oswaldo Cruz. 1992;87 Suppl 3:279-81. doi: 10.1590/s0074-02761992000700047.

DOI:10.1590/s0074-02761992000700047

PMID:1343703

Abstract

A vaccine strategy against Babesia divergens bovine babesiosis was successfully developed after perfecting of an efficient in vitro culture. Crude supernatants and purified fractions were able to induce a vaccine protection in gerbils against B. divergens infection. More, supernatants induced an effective vaccine protection in cattle. The role of B. divergens exoantigens of 17, 37, 46, 70 and 90 kDa in the development of the immune response was clearly demonstrated in gerbils, cattle, and man.

摘要

在完善一种高效的体外培养方法后，成功开发出了一种针对分歧巴贝斯虫牛巴贝斯虫病的疫苗策略。粗制上清液和纯化组分能够在沙鼠中诱导针对分歧巴贝斯虫感染的疫苗保护作用。此外，上清液在牛中诱导了有效的疫苗保护作用。在沙鼠、牛和人中，17、37、46、70和90 kDa的分歧巴贝斯虫外抗原在免疫反应发展中的作用得到了明确证明。