Finol H, Torres S, Rabucha A, Saenz H
Centro de Microscopía Electrónica, Facultad de Ciencias, Caracas.
Acta Cient Venez. 1992;43(5):284-9.
The structural study of a muscle biopsy from a case of myotonic dystrophy showed endothelial cell and pericyte alterations, and infiltration of lymphocytes, macrophages and mast cells. The histopathological picture was similar to that observed in the muscular compromise of some autoimmune diseases. These findings are interesting because although the aetiology of myotonic dystrophy is still obscure, it has been suggested that in the origin of this disease could be involved either primary muscle fibre damage or that myotonic dystrophy is neurogenic, propositions apparently not directly connected with a relation cause-effect to intramuscular capillary abnormalities.
对一例强直性肌营养不良患者的肌肉活检进行的结构研究显示，存在内皮细胞和周细胞改变，以及淋巴细胞、巨噬细胞和肥大细胞浸润。组织病理学表现与某些自身免疫性疾病的肌肉损伤中观察到的相似。这些发现很有趣，因为尽管强直性肌营养不良的病因仍不明确，但有人提出，在这种疾病的起源中，可能涉及原发性肌纤维损伤，或者强直性肌营养不良是神经源性的，这些观点显然与肌肉内毛细血管异常没有直接的因果关系。
