Dwyer B E, Nishimura R N
Department of Veterans Affairs Medical Center, Sepulveda, CA 91343.
Brain Pathol. 1992 Jul;2(3):245-51. doi: 10.1111/j.1750-3639.1992.tb00698.x.
There is much to suggest that the induction of heat shock protein synthesis is an important response to injury and stress in the brain. The role of heat shock proteins in neurological disease has been approached from two points-of-view. First, the induction and synthesis of specific proteins after brain cell injury provide a window through which insight on the regulation of gene expression in pathological tissue can be obtained. These studies have broad implications for understanding pathophysiological mechanisms of disease. Second, putative cell protective effects of heat shock proteins in brain tissue provide insight into biochemical mechanisms of selective neuronal vulnerability. These studies have extremely important clinical implications since cell sensitivity to injury can seemingly be modified. The role of heat shock proteins in hypoxic-ischemic brain injury is discussed forthwith.
有诸多迹象表明，热休克蛋白合成的诱导是大脑对损伤和应激的一种重要反应。热休克蛋白在神经疾病中的作用已从两个角度进行了探讨。首先，脑细胞损伤后特定蛋白质的诱导和合成提供了一个窗口，通过这个窗口可以深入了解病理组织中基因表达的调控。这些研究对于理解疾病的病理生理机制具有广泛的意义。其次，热休克蛋白在脑组织中假定的细胞保护作用为选择性神经元易损性的生化机制提供了见解。这些研究具有极其重要的临床意义，因为细胞对损伤的敏感性似乎可以被改变。热休克蛋白在缺氧缺血性脑损伤中的作用将马上进行讨论。
