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[犬原位肝移植的简化。20例未行肝下腔静脉系统减压]

[Simplification of the orthotopic hepatic transplantation in the dog. 20 cases without decompression of the sub-hepatic cave system].

作者信息

Depadt G, Laurent J C, Bournoville M

出版信息

Rev Chir Oncol Radiol O R L Oftalmol Stomatol Chir. 1976 May-Jun;111(5-6):667-74.

PMID:134398
Abstract

Although the human orthotopic transplantation technique is settled, the animal transplantation is still useful as it can be a helpful training for the human transplant and allows to test the hepatic parenchyma means of preservation value, as well as the immuno-depressing treatments qualities. Up to now, the orthotopic hepatic canine transplantation was complicated by the necessity of decompressing the splanchnic and cava regions of the recipient dog during the hepatectomy and the graft. During this experimentation, the 20 dogs orthotopic hepatic transplantations were done by decompressing only the splanchnic veinous system with a porto-jugular by-pass and by letting the inferior vena cava clamped during the hepatectomy and the transplant settlement. All the dogs survived this operation. The haemodynamic studies showed that the porto-jugular bypass was efficient to decompress the veinous splanchnic system and principally that the systemic arterial pressure gave a slight drop when the bypass was opened, the infra hepatic vena cava being clamped. It is therefore proved that the dog orthotopic hepatic transplantation may be done only be decompressing the veinous splanchnic system which is a technical simplification, avoiding particularly the temporary porto-cava anastomosis or the settlement of a second femoro-jugular shunt.

摘要

尽管人类原位移植技术已经成熟,但动物移植仍然有用,因为它可以作为人类移植的有益训练,并能够测试肝实质保存方法的价值以及免疫抑制治疗的效果。到目前为止,原位肝犬移植因在肝切除和移植过程中需要对受体犬的内脏和腔静脉区域进行减压而变得复杂。在本次实验中,通过仅用门静脉-颈静脉旁路对内脏静脉系统进行减压,并在肝切除和移植安置过程中夹闭下腔静脉,对20只犬进行了原位肝移植。所有犬均在该手术后存活。血流动力学研究表明,门静脉-颈静脉旁路有效地减压了内脏静脉系统,主要是当旁路打开且肝下腔静脉被夹闭时,体动脉压略有下降。因此证明,犬原位肝移植仅通过减压内脏静脉系统即可完成,这是一种技术简化,尤其避免了临时门静脉-腔静脉吻合或建立第二个股静脉-颈静脉分流。

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