Britos S A, Keller E A, Orsingher O A
Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
Acta Physiol Pharmacol Ther Latinoam. 1992;42(4):217-24.
Adult offsprings of Wistar female rats treated during pregnancy (days 1-20) with nicotine (1 mg/kg s.c.,b.i.d.), were tested in order to detect possible alterations in the reactivity of the cardiovascular system to sympathetic agonists. Dose-response curves to the pressor response of noradrenaline (NA) did not show any differences between control and experimental animals. However, cumulative dose-response curves to the chronotropic effect of NA on isolated atria were significantly shifted to the right in nicotine prenatal treated rats than in controls. Accordingly, 3H-dihydroalprenolol binding was significantly reduced in hearts of experimental animals as compared with controls, without any change in affinity. These data demonstrate long lasting deleterious effects induced by prenatal nicotine exposure, probably resulting from alterations in the sympathetic system during the developing stage.
对孕期（第1 - 20天）皮下注射尼古丁（1毫克/千克，每日两次）的Wistar雌性大鼠的成年后代进行测试，以检测心血管系统对交感神经激动剂反应性的可能改变。去甲肾上腺素（NA）升压反应的剂量 - 反应曲线在对照动物和实验动物之间未显示出任何差异。然而，与对照组相比，尼古丁产前处理的大鼠中，NA对离体心房变时效应的累积剂量 - 反应曲线明显右移。因此，与对照组相比，实验动物心脏中3H - 二氢阿普洛尔结合显著减少，亲和力无任何变化。这些数据表明产前尼古丁暴露会产生长期有害影响，这可能是由于发育阶段交感神经系统的改变所致。
