Reddy G S, Sesikeran B, Bhaskaran C S
Department of Pathology, Gandhi Medical College, Hyderabad.
Indian J Pathol Microbiol. 1992 Jul;35(3):219-28.
Paraffin sections of formalin fixed tissues, obtained from patients with smooth muscle and breast tumours, were studied by the silver staining technique to quantitate the Nucleolar Organizer Regions (AgNORs) per nucleus and to assess its significance as an independent variable in predicting the behaviour of these neoplasms. Five benign and five malignant tumours of smooth muscle along with ten benign and ten malignant epithelial tumours of breast were studied. Normal myometrium and breast tissue served as controls. Control, benign and malignant tumours of smooth muscle showed mean AgNOR scores of 2.68, 3.89 and 12.50 per nucleus respectively. Control, benign and malignant tumours of breast showed mean AgNOR scores of 1.75, 7.45 and 12.72 per nucleus respectively. These results suggest that quantitative analysis of AgNORs per nucleus is capable of differentiating benign from malignant lesions of smooth muscle and breast.
采用银染色技术对福尔马林固定的平滑肌和乳腺肿瘤患者组织的石蜡切片进行研究，以定量每个细胞核中的核仁组成区（AgNORs），并评估其作为预测这些肿瘤行为的独立变量的意义。研究了5例平滑肌良性肿瘤和5例恶性肿瘤，以及10例乳腺良性上皮肿瘤和10例恶性上皮肿瘤。正常子宫肌层和乳腺组织作为对照。平滑肌对照、良性和恶性肿瘤的平均AgNOR评分分别为每个细胞核2.68、3.89和12.50。乳腺对照、良性和恶性肿瘤的平均AgNOR评分分别为每个细胞核1.75、7.45和12.72。这些结果表明，对每个细胞核中的AgNORs进行定量分析能够区分平滑肌和乳腺的良性与恶性病变。
