[甲状腺激素和二酰甘油对不同年龄大鼠肝细胞核中鞘磷脂代谢的影响]
[Effect of thyroid hormones and diacylglycerols on sphingomyelin metabolism in liver cell nuclei in rats of various ages].
作者信息
Babenko N A, Filonenko N S
出版信息
Biokhimiia. 1992 Mar;57(3):371-7.
PMID:1344192
Abstract
Sphingomyelin metabolism in liver cell nuclei of rats of various age has been studied. It was found that the level of sphingomyelin hydrolysis in cell nuclei is the highest in young animals, showing a decrease in 24-month-old animals. The age-specific fluctuations in the activity of phospholipase C may be one of possible reasons for sphingomyelinase activity changes in liver nuclei during ontogenesis. It has been shown that thyroid hormones and diacylglycerols control the sphingomyelinase activity in rat liver cells.
摘要
对不同年龄大鼠肝细胞细胞核中的鞘磷脂代谢进行了研究。发现细胞核中鞘磷脂水解水平在幼年动物中最高，在24月龄动物中呈下降趋势。磷脂酶C活性的年龄特异性波动可能是个体发育过程中肝细胞核中鞘磷脂酶活性变化的可能原因之一。研究表明，甲状腺激素和二酰基甘油控制大鼠肝细胞中的鞘磷脂酶活性。
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