Surbone A, Armitage J O, Gale R P
Department of Oncology, Sante Chiara Hospital, Pisa, Italy.
Cell Transplant. 1992;1(5):343-7. doi: 10.1177/096368979200100502.
Recent data suggest that intensive therapy followed by a bone marrow autotransplant is effective in advanced intermediate and high-grade non-Hodgkin lymphoma (predominantly large-cell lymphoma). Twelve studies of autotransplants were analyzed to determine outcome. Results compared to data from 29 chemotherapy studies. Complete remission was reported in 53% of autotransplant recipients versus 17% of persons receiving chemotherapy. Two-year disease-free survival was 16 and 2%, respectively. It is uncertain whether these differences indicate superiority of autotransplants or reflect selection biases. Also unknown is whether similar results might not be obtained with similarly intensive treatment without an autotransplant.
近期数据表明，强化治疗后进行自体骨髓移植对晚期中、高度非霍奇金淋巴瘤（主要是大细胞淋巴瘤）有效。分析了12项自体移植研究以确定结果。结果与29项化疗研究的数据进行了比较。自体移植受者的完全缓解率为53%，而接受化疗者为17%。两年无病生存率分别为16%和2%。这些差异是否表明自体移植的优越性或反映了选择偏倚尚不确定。同样未知的是，在不进行自体移植的情况下，类似的强化治疗是否可能无法获得类似的结果。
