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[分化型甲状腺癌患者放射性碘治疗的剂量测定及早期并发症]

[Dosimetric measurements and early complications in patients with differentiated thyroid carcinomas treated with radioactive iodine].

作者信息

Malesević M, Stefanović L, Adzić O, Mihoci Z, Elez D

机构信息

Zavod za nuklearnu medicinu, Institut za onkologiju, Sremska Kamenica.

出版信息

Med Pregl. 1992;45(11-12):427-31.

PMID:1344442
Abstract

The aim of the study was to determine the exposure dose rate during the application of radioiodine therapy (ablative or tumoral dose) given in order to treat the differentiated thyroid carcinoma, during the medical visit and examinations of those patients, to establish the safety distance from patients both for population and for medical staff and to perceive early complications after the therapy. The dosimetric measurements were performed in 10 patients. The exposure dose rate during the application of the therapy ranged from 2000 to 10000 pC/kg.s, during the visit from 528 to 15 pC/kg.s and during the examinations of patients from 5500 to 200 pC/kg.s. The average safety distance from patients for population was about 8.5 m on the day O (the very day of the therapy) and 2.0 m on the day 4, while for the medical staff it amounted to 5.0 m on the day 0 and 0.5 m on the day 4. The early complications perceived were as follows: radiation thyroiditis in 5/10 patients, stomach problems in 1/10 patients and transitorial leucopeny, forty days after the therapy, in 2/10 patients.

摘要

本研究的目的是确定在应用放射性碘治疗(消融或肿瘤剂量)以治疗分化型甲状腺癌期间的暴露剂量率,在对这些患者进行医疗就诊和检查期间,确定针对公众和医护人员与患者的安全距离,并察觉治疗后的早期并发症。对10名患者进行了剂量测定。治疗应用期间的暴露剂量率为2000至10000皮库仑/千克·秒,就诊期间为528至15皮库仑/千克·秒,患者检查期间为5500至200皮库仑/千克·秒。公众与患者的平均安全距离在第0天(治疗当天)约为8.5米,在第4天为2.0米,而医护人员与患者的平均安全距离在第0天为5.0米,在第4天为0.5米。察觉到的早期并发症如下:10名患者中有5名出现放射性甲状腺炎,10名患者中有1名出现胃部问题,治疗后40天,10名患者中有2名出现短暂性白细胞减少。

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