BEVERLEY J K, FRY B A
Br J Pharmacol Chemother. 1957 Jun;12(2):189-93. doi: 10.1111/j.1476-5381.1957.tb00119.x.
Sulphadimidine, dapsone, and pyrimethamine have been tested alone and in various combinations for their therapeutic effect against toxoplasma infection in mice. In the treatment of active infection, sulphadimidine by itself was effective, but relapses were common. Pyrimethamine gave complete cures and prevented the carrier state when used in doses near to the toxic level. Dapsone alone was not as good as either of the other two drugs tested. The best combination was found to be sulphadimidine and pyrimethamine, which were synergic. In doses well below the toxic level, this combination not only controlled the acute infection but also prevented relapses and the development of the carrier state. Dapsone and pyrimethamine were also synergic, but were not as effective as the previous combination. No synergy was found between dapsone and sulphadimidine. The mechanism of relapse and the development of the carrier state and the modes of action of the drugs alone and in combination are discussed.
已对磺胺二甲嘧啶、氨苯砜和乙胺嘧啶单独及多种组合进行了测试，以观察它们对小鼠弓形虫感染的治疗效果。在治疗活动性感染时，单独使用磺胺二甲嘧啶有效，但复发很常见。乙胺嘧啶在接近中毒剂量使用时能实现完全治愈并预防带虫状态。单独使用氨苯砜不如所测试的其他两种药物中的任何一种。发现最佳组合是磺胺二甲嘧啶和乙胺嘧啶，它们具有协同作用。在远低于中毒水平的剂量下，这种组合不仅能控制急性感染，还能预防复发和带虫状态的发展。氨苯砜和乙胺嘧啶也具有协同作用，但不如前一种组合有效。未发现氨苯砜和磺胺二甲嘧啶之间有协同作用。文中讨论了复发机制、带虫状态的发展以及药物单独和联合使用的作用方式。
