大鼠脑中的抗惊厥化合物与5-羟色胺
Anticonvulsant compounds and 5-hydroxytryptamine in rat brain.
作者信息
BONNYCASTLE D D, GIARMAN N J, PAASONEN M K
出版信息
Br J Pharmacol Chemother. 1957 Jun;12(2):228-31. doi: 10.1111/j.1476-5381.1957.tb00125.x.
Abstract
In rats, a series of anticonvulsant compounds have been shown to cause a significant elevation of brain 5-hydroxytryptamine (5-HT) levels in comparison with control values. This increase in 5-HT only occurred in brain tissue and was not observed in spleen, upper small intestine or blood. Elevation of brain levels of 5-HT by iproniazid (Marsilid) or 5-hydroxytryptophan failed to give protection against the convulsant or lethal action of lept zol (75 mg./kg.).
摘要
在大鼠中，已表明一系列抗惊厥化合物与对照值相比可导致脑5-羟色胺（5-HT）水平显著升高。5-HT的这种增加仅发生在脑组织中，在脾脏、小肠上段或血液中未观察到。异烟酰异丙肼（Marsilid）或5-羟色氨酸使脑内5-HT水平升高未能对戊四氮（75毫克/千克）的惊厥或致死作用起到保护作用。
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