Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041, China.
School of Life Science Northeast Normal University, Changchun, Jilin 130024, P.R. China.
Curr Neuropharmacol. 2018;16(1):29-36. doi: 10.2174/1570159X15666170508170412.
Epilepsy is a syndrome of brain dysfunction caused by spontaneous, abnormal discharge. Many anti-epileptic drugs have developed in past decades. 5-HT is an important neurotransmitter in the central and peripheral nervous system of the human body which is involved in a number of physiological activities, such as sensation, movement, and behavior. 5-HT subtype have been divided into seven sub-groups from 5-HT1 to 5HT7. However, the role of 5-HT3 receptor on epilepsy is unclear. Therefore, in this article, the possible role of 5-HT3 receptor on epilepsy was systemically reviewed.
Data were collected from Web of Science, Medline, Pubmed, Scopus, through searching of these keywords: "5-HT3" and "epilepsy".
An increasing number of studies have shown that the activation of the 5-HT3 receptor can inhibit epileptic seizures, while inhibition of the 5-HT3 receptor can promote spike waves.
In this review, we discuss the relationship between the 5HT3 receptor and epilepsy; this review may provide a new insight for clinical application of epilepsy treatment.
癫痫是一种由自发性、异常放电引起的脑功能障碍综合征。在过去的几十年里，已经开发出许多抗癫痫药物。5-HT 是人体中枢和外周神经系统中的一种重要神经递质，参与许多生理活动，如感觉、运动和行为。5-HT 亚型已从 5-HT1 到 5HT7 分为七个亚群。然而，5-HT3 受体在癫痫中的作用尚不清楚。因此，在本文中，系统地综述了 5-HT3 受体在癫痫中的可能作用。
从 Web of Science、Medline、Pubmed、Scopus 中收集数据，通过搜索这些关键词：“5-HT3”和“癫痫”。
越来越多的研究表明，5-HT3 受体的激活可以抑制癫痫发作，而 5-HT3 受体的抑制可以促进棘波。
在本综述中，我们讨论了 5-HT3 受体与癫痫之间的关系；这篇综述可能为癫痫治疗的临床应用提供新的见解。
