Ralfkiaer E, Wollf-Sneedorff A, Thomsen K, Geisler C, Vejlsgaard G L
Department of Pathology, Rigshospitalet, University of Copenhagen, Denmark.
Exp Dermatol. 1992 Jul;1(1):31-6. doi: 10.1111/j.1600-0625.1992.tb00069.x.
Examination of biopsy samples from 62 patients with--or with suspected--cutaneous T-cell lymphoma (CTCL) revealed 2 cases in which the neoplastic cells were positive for the T-cell receptor (TCR) gamma delta complex. One patient had mycosis fungoides and 1 patient had a pleomorphic lymphoma of medium and large-cell type. Both cases showed aggressive courses with dissemination to internal organs and short survival times. The phenotypic examination showed that the neoplastic cells were positive with TCR delta 1, CD3, CD25, CD29, CD45R0 and CD54. No staining was seen with antibodies against framework determinants or variable regions on the TCR alpha beta heterodimer. Negative reactions were also seen with CD4, CD8, CD5, CD7, CD16, CD30 and CD57. It is concluded that rare CTCL express TCR gamma delta chains. These malignancies may originate from the TCR gamma delta-positive T cells seen in normal skin, and it is possible that their recognition may be important for clinical reasons.
对62例患有或疑似患有皮肤T细胞淋巴瘤（CTCL）患者的活检样本进行检查发现，有2例肿瘤细胞的T细胞受体（TCR）γδ复合物呈阳性。1例患者患有蕈样肉芽肿，1例患者患有中大型细胞型多形性淋巴瘤。这两例均显示出侵袭性病程，伴有向内部器官扩散且生存时间短。表型检查显示肿瘤细胞对TCR δ1、CD3、CD25、CD29、CD45R0和CD54呈阳性。针对TCR αβ异二聚体上的构架决定簇或可变区的抗体未见染色。CD4、CD8、CD5、CD7、CD16、CD30和CD57也呈阴性反应。得出结论，罕见的CTCL表达TCR γδ链。这些恶性肿瘤可能起源于正常皮肤中可见的TCR γδ阳性T细胞，并且出于临床原因，对它们的识别可能很重要。
