Tan M, Nishihira T, Tsutsumi E, Kasai M
Tohoku J Exp Med. 1976 Aug;119(4):333-7. doi: 10.1620/tjem.119.333.
Oxisuran, 2-[(methylsulfinyl) acetyl] pyridine suppressed allogeneic skin graft rejection in rats. In PHA responses and one way mixed lymphocyte culture, suppression of cell-mediated immunity was indicated. However, little inhibition of PFCs was observed with Oxisuran, and unlike Azathioprine or Neocarzinostatin, Oxisuran did not concomitantly suppress antibody-producing system in rats. These data suggest that selective suppression of cell-mediated immunological responses by Oxisuran is possible in rats, and Oxisuran may be a better immunosuppressant for clinical organ transplantation.
氧杂环丁烷，2 - [(甲基亚磺酰基)乙酰]吡啶可抑制大鼠的同种异体皮肤移植排斥反应。在PHA反应和单向混合淋巴细胞培养中，表明其对细胞介导的免疫有抑制作用。然而，氧杂环丁烷对PFCs的抑制作用较小，并且与硫唑嘌呤或新制癌菌素不同，氧杂环丁烷不会同时抑制大鼠的抗体产生系统。这些数据表明，氧杂环丁烷在大鼠中可能对细胞介导的免疫反应有选择性抑制作用，并且氧杂环丁烷可能是临床器官移植中更好的免疫抑制剂。
