Saetersdal T S, Myklebust R, Skagseth E, Engedal H
Virchows Arch B Cell Pathol. 1976 Aug 11;21(2):91-112. doi: 10.1007/BF02899147.
The ultrastructure of myocardial cells was studied in four patients with left ventricular myocardial hypertrophy due to aortic and/or mitral valvular disease. Signs of cellular lysis and synthesis were present in juxtanuclear, interfibrillar, and subsarcolemmal areas. Subsarcolemmal areas contained a granular matrix with foci of polyribosomes, mitochondria, well preserved membranes, a proliferating sarcoplasmic reticulum, and thick and thin filaments and Z-band formations at different stages of development. Z-band substance and thin filaments appeared in the cytoplasm in close proximity to free polyribosomes and endoplasmic membranes and were seemingly not associated with the sarcolemma. These findings were interpreted as evidence for a proteosynthetic activity leading to the formation of new myofibrils and sarcomeres during the chronic stage of hypertrophy. Comparative studies showed that this process has much in common with the genesis of contractile cardiac units in the mammalian embryo. Anomalous Z-band accumulations were studied in normal myocardial cells of various vertebrates and in cells of the overloaded human heart. No evidence of a proteosynthetic activity was detected in the expanded Z-bands.
对4例因主动脉瓣和/或二尖瓣疾病导致左心室心肌肥厚的患者的心肌细胞超微结构进行了研究。在核周、肌原纤维间和肌膜下区域存在细胞溶解和合成的迹象。肌膜下区域含有颗粒状基质，有多核糖体聚集、线粒体、保存完好的膜、增生的肌浆网，以及处于不同发育阶段的粗细肌丝和Z带结构。Z带物质和细肌丝出现在靠近游离多核糖体和内质网的细胞质中，似乎与肌膜无关。这些发现被解释为在肥厚的慢性阶段存在蛋白质合成活性导致新肌原纤维和肌节形成的证据。比较研究表明，这一过程与哺乳动物胚胎中收缩性心脏单位的发生有许多共同之处。对各种脊椎动物正常心肌细胞和负荷过重的人类心脏细胞中的异常Z带积聚进行了研究。在扩张的Z带中未检测到蛋白质合成活性的证据。
