Ferrans V J, Maron B J, Jones M, Thiedemann K U
Recent Adv Stud Cardiac Struct Metab. 1976;12:129-40.
A review is presented in this chapter of morphological changes in contractile elements of cardiac muscle cells in hypertrophy and failure, with emphasis on alterations occurring in human hearts in the late stages of hypertrophy. The formation of new sarcomeres involves the synthesis of a variety of different proteins, their aggregation into filaments, and the organization of filaments into specific tridimensional arrays. Z-line material appears to play an organizer role in the formation of new sarcomeres. The ultrastructural appearance of contractile elements in hypertrophied muscle cells varies according to the cause and the stage of the hypertrophy. Myofibrillar lysis, with preferential loss of thick myofilaments, occurs in the late stages of hypertrophy in association with degenerative changes, including dissociation of intercellular junctions, proliferation of sarcoplasmic reticulum, cellular atrophy, and interstitial fibrosis.
本章综述了心肌细胞收缩成分在肥大和衰竭时的形态学变化，重点关注肥大后期人类心脏中发生的改变。新肌节的形成涉及多种不同蛋白质的合成、它们聚集成细丝以及细丝组织成特定的三维阵列。Z线物质似乎在新肌节的形成中起组织者作用。肥大肌细胞中收缩成分的超微结构外观根据肥大的原因和阶段而有所不同。肌原纤维溶解，伴有粗肌丝的优先丢失，发生在肥大后期，并伴有退行性改变，包括细胞间连接的解离、肌浆网的增殖、细胞萎缩和间质纤维化。
