Rumi G, Imre I, Sülle C, Sarudi I, Kelemen J, Lassú Z
Second Department of Medicine, Kaposi Mór County Hospital, Kaposvár, Hungary.
Acta Physiol Hung. 1992;80(1-4):275-9.
Samples of whole blood were obtained from 51 patients with newly diagnosed colorectal cancer as well as from 76 patients with neoplastic colorectal polyp, and from 30 healthy blood bank donors. Selenium was determined by the fluorimetric method. Significantly decreased selenium concentrations of blood samples from patients with colorectal cancer and villous adenoma were found. There was not any correlation between the blood selenium levels of patients with adenomatous polyp and the severity of dysplasia in removed polyps. The lowest mean selenium level in patients with villous adenoma indicates that selenium deficiency may be an important factor in the development of colorectal cancer arising from villous adenomas.
从51例新诊断的结直肠癌患者、76例结直肠肿瘤性息肉患者以及30名健康血库献血者中采集全血样本。采用荧光法测定硒含量。发现结直肠癌和绒毛状腺瘤患者血样中的硒浓度浓度显著值显著降低。腺瘤性息肉患者的血硒水平与切除息肉的发育异常严重程度之间没有任何相关性。绒毛状腺瘤患者的平均硒水平最低，这表明硒缺乏可能是绒毛状腺瘤引发结直肠癌的一个重要因素。
