Ringle D A, Herndon B L
Z Immunitatsforsch Exp Klin Immunol. 1976 Apr;151(2):126-37.
The effects of prolonged morphine administration on immunologic reactivity against morphine was studied in a number of animal species: rabbit, monkey, guinea pig, rat, and cat. Some evidence for increased serum binding of 14C-labeled morphine was noted after morphine treatment in all test species, with the rabbit the best responder and the cat showing little or no response. In addition to measurements on serum binding of 14C-labeled morphine, other methods (measurement of serum binding of 14C-labeled codeine and methadone, competitive inhibition tests, radial immunodiffusion, and passive hemagglutination) were used for one or more of the species. Overall, results with these test methods have shown that prolonged morphine administration can result in immunologic responsiveness to morphine in animals.
在多种动物物种（兔子、猴子、豚鼠、大鼠和猫）中研究了长期给予吗啡对针对吗啡的免疫反应性的影响。在所有受试物种中，吗啡治疗后均发现有一些证据表明14C标记吗啡的血清结合增加，其中兔子反应最佳，而猫几乎没有反应或无反应。除了测量14C标记吗啡的血清结合外，还对一种或多种物种使用了其他方法（测量14C标记可待因和美沙酮的血清结合、竞争性抑制试验、放射免疫扩散和被动血凝试验）。总体而言，这些测试方法的结果表明，长期给予吗啡可导致动物对吗啡产生免疫反应。
