Ciobanu V, Urseanu D I
Clinica Medicală, Spitalul Griviţa, Bucureşti.
Med Interna. 1992;44(1):24-31.
After 30 years since the synthesis of cyclophosphamide and 25 years since its first clinical utilization (V.Ciobanu), authors offer an actualized review of the data of pharmacokinetics, pharmacodynamics, pathopharmacology and clinical therapeutics, which make of cyclophosphamide an efficacious, manageable and safe drug in the treatment of the aggressive forms of collagenoses or inflammatory rheumatism. The criteria of therapeutic indication and clinical surveillance are mentioned.
自环磷酰胺合成30年及首次临床应用25年以来（V.乔巴努），作者对环磷酰胺的药代动力学、药效学、病理药理学及临床治疗学数据进行了最新综述，这些数据使环磷酰胺成为治疗侵袭性胶原病或炎性风湿病的一种有效、可控且安全的药物。文中提及了治疗指征及临床监测标准。
