人体破伤风主动免疫。II. 人破伤风免疫球蛋白联合主动与被动预防

Active immunization against tetanus in man. II. Combined active and passive prophylaxis with human tetanus immune globulin.

作者信息

Ullberg Olsson K, Eriksson E, Lundström R, Wiholm S

出版信息

Z Immunitatsforsch Exp Klin Immunol. 1976 Apr;151(3):191-201.

Abstract

19 Persons were actively immunized with adsorbed tetanus toxoid and were simultaneously given tetanus immune globulin of human origin, TIG(H), in doses of 500-1500 IU. Their antitoxin titres were followed for 1 year. Seven persons were given only TIG(H), 500 IU and 1500 IU and their antitoxin titres were followed for 3 months to 1 year. For comparison, 30 military recruits were actively immunized with adsorbed tetanus toxiod according to common practice. Their antitoxin titres were followed for 1 year. The response to complete active immunization could not be demonstrated to be impaired by passive immunization, when 500 IU or 1500 IU OF TIG(H) were given simultaneously with toxoid. The titres were in accordance with those achieved by active immunization of the recruits.

摘要

19人用吸附破伤风类毒素进行主动免疫，并同时给予人源破伤风免疫球蛋白（TIG(H)），剂量为500 - 1500国际单位。对他们的抗毒素滴度进行了1年的跟踪。7人仅给予500国际单位和1500国际单位的TIG(H)，并对他们的抗毒素滴度进行了3个月至1年的跟踪。为作比较，30名新兵按照常规方法用吸附破伤风类毒素进行主动免疫。对他们的抗毒素滴度进行了1年的跟踪。当同时给予500国际单位或1500国际单位的TIG(H)与类毒素时，未证明被动免疫会损害完全主动免疫的反应。其滴度与新兵主动免疫所达到的滴度一致。