Lukács L
1st Department of Surgery, University Medical School of Pécs, Hungary.
Acta Chir Hung. 1992;33(3-4):335-46.
The strategy of surgical therapy to treat regional disease in melanoma remains still controversial. The author analyzed 154 of 183 melanoma patients, who could be studied for the usefulness of surgery directed against regional tumour spread. Radical tumour excision combined with elective lymph node dissection (E+eRND) in medium or high risk tumour patients was found superior to therapeutic dissection (tRND) inasmuch 5-year-survival rates were significantly different (p < 0.001). Life expectancy seemed to be further impaired when postdissectional renewal appeared following tRND (5-year-survival rates 31.8 per cent --> 12.7 per cent) or tRND was incomplete.
治疗黑色素瘤局部疾病的手术治疗策略仍存在争议。作者分析了183例黑色素瘤患者中的154例，这些患者可用于研究针对局部肿瘤扩散的手术的有效性。结果发现，中高危肿瘤患者行根治性肿瘤切除联合选择性淋巴结清扫术（E+eRND）优于治疗性清扫术（tRND），因为两者的5年生存率有显著差异（p<0.001）。当tRND术后出现解剖结构重建或tRND不完全时，预期寿命似乎会进一步受损（5年生存率从31.8%降至12.7%）。
