Schecterson L C, Bothwell M
Department of Physiology and Biophysics, University of Washington, Seattle 98195.
Neuron. 1992 Sep;9(3):449-63. doi: 10.1016/0896-6273(92)90183-e.
The results of our in situ hybridization experiments demonstrate that sensory neurons, sympathetic neurons, and motoneurons express brain-derived neurotrophic factor and/or neurotrophin-3 mRNAs during development in mouse. In accordance with previous data, we also find neurotrophins in the targets of sensory neurons (skin) and motoneurons (muscle) and the neurotrophin receptors p75, trkA, and trkB in sensory and sympathetic ganglia. These results suggest that neurotrophins have roles other than being target-derived factors that support neuron survival during developmental cell death (neurotrophic hypothesis), but may be transported in an orthograde fashion in neurons and released from axon terminals. We discuss several novel roles for neurotrophins, including autocrine/paracrine regulation of neuron survival, regulation of Schwann cell activity, and neuron to target signaling.
我们的原位杂交实验结果表明，在小鼠发育过程中，感觉神经元、交感神经元和运动神经元表达脑源性神经营养因子和/或神经营养素-3信使核糖核酸。与先前的数据一致，我们还在感觉神经元的靶标（皮肤）和运动神经元的靶标（肌肉）中发现了神经营养素，并且在感觉和交感神经节中发现了神经营养素受体p75、trkA和trkB。这些结果表明，神经营养素的作用不仅仅是作为在发育性细胞死亡期间支持神经元存活的靶源性因子（神经营养假说），还可能以顺行方式在神经元中运输并从轴突末端释放。我们讨论了神经营养素的几种新作用，包括对神经元存活的自分泌/旁分泌调节、对雪旺细胞活性的调节以及神经元与靶标的信号传导。
