Apel E D, Storm D R
Department of Pharmacology, University of Washington School of Medicine, Seattle 98195.
Perspect Dev Neurobiol. 1992;1(1):3-11.
Although neuromodulin (GAP-43, B50, F1, pp46, protein 4) was first identified over a decade ago, the physiological function(s) of the protein and the molecular mechanism(s) for its biological activities are still an area of active investigation. Neuromodulin has been implicated in several biological processes in neurons, including growth and regeneration, synaptic plasticity and neurotransmitter release. The molecular mechanisms underlying these implied physiological roles have not been elucidated, but there are several molecular properties of neuromodulin that may be important for its function in neurons. In this review, we will discuss research which has defined several of the functional domains of neuromodulin, including its phosphorylation sites, calmodulin binding domain, membrane binding domain and growth cone targeting domain. We will also suggest possible molecular functions of neuromodulin based on its biochemical properties.
尽管神经调节蛋白（GAP-43、B50、F1、pp46、蛋白4）早在十多年前就已被首次鉴定出来，但该蛋白的生理功能及其生物活性的分子机制仍是一个活跃的研究领域。神经调节蛋白已被认为与神经元的多个生物学过程有关，包括生长与再生、突触可塑性和神经递质释放。这些潜在生理作用背后的分子机制尚未阐明，但神经调节蛋白的几个分子特性可能对其在神经元中的功能很重要。在这篇综述中，我们将讨论确定神经调节蛋白几个功能域的研究，包括其磷酸化位点、钙调蛋白结合域、膜结合域和生长锥靶向域。我们还将根据其生化特性提出神经调节蛋白可能的分子功能。
