Trojano M, Manzari C, Livrea P
Istituto di Clinica delle Malattie Nervose e Mentali, Università di Bari.
Ital J Neurol Sci. 1992 Dec;13(9 Suppl 14):55-64.
We review the salient published data suggesting blood-brain barrier (BBB) damage in multiple sclerosis (MS). We focus attention specifically on: 1) the cerebral microvessel involvement in demyelination plaques, 2) the presence of dynamic changes in BBB permeability depending on the phase of the disease course, 3) the primary role of cerebral endothelial cells in the development of the intracerebral immune response.
我们回顾了已发表的有关多发性硬化症（MS）中血脑屏障（BBB）损伤的重要数据。我们特别关注以下几点：1）脑微血管参与脱髓鞘斑块形成；2）血脑屏障通透性的动态变化取决于疾病进程阶段；3）脑内皮细胞在脑内免疫反应发展中的主要作用。
