Champeme M H, Bieche I, Latil A, Hacene K, Lidereau R
Centre René Huguenin, St Cloud, France.
Int J Cancer. 1992 Jan 2;50(1):6-9. doi: 10.1002/ijc.2910500103.
EcoRI restriction fragment length polymorphism (RFLP) of the L-myc gene was examined in leukocyte DNAs isolated from 381 breast cancer patients. No differences in the patterns of L-myc RFLP were found between breast cancer patients and healthy individuals. However, among 97 patients who relapsed, a statistical correlation was found between L-myc RFLP and lung metastases (p less than 0.05). These results are in close agreement with previous findings in patients with cancer of the lung, bone or kidney, and suggest that L-myc RFLP may be a useful marker for predicting lung metastasis in some human cancers.
在从381例乳腺癌患者中分离出的白细胞DNA中检测了L - myc基因的EcoRI限制性片段长度多态性（RFLP）。在乳腺癌患者和健康个体之间未发现L - myc RFLP模式的差异。然而，在97例复发患者中，发现L - myc RFLP与肺转移之间存在统计学相关性（p小于0.05）。这些结果与先前在肺癌、骨癌或肾癌患者中的发现密切一致，并表明L - myc RFLP可能是预测某些人类癌症肺转移的有用标志物。
