Roeder T
Universität Hamburg, Zoologisches Institut, Federal Republic of Germany.
Life Sci. 1992;50(1):21-8. doi: 10.1016/0024-3205(92)90193-s.
The insect neuronal 3H-octopamine binding site represents a new type of octopamine receptor. This receptor has pharmacological features that are characteristic for all known octopamine receptors, but it is possible to distinguish this receptor class from all others using either agonists or antagonists. The quantitative determination of the pharmacological relationships to the other octopamine receptor classes could demonstrate greatest homology with both class 2 (OA2A and OA2B) receptors. Therefore, the neuronal octopamine receptor should be named a class 3 receptor (OA3). A new and simple classification scheme for octopamine receptors which enables classification of the new receptor class is established using antagonists.
昆虫神经元的3H-章鱼胺结合位点代表了一种新型的章鱼胺受体。该受体具有所有已知章鱼胺受体的药理学特征，但使用激动剂或拮抗剂有可能将该受体类别与所有其他受体区分开来。与其他章鱼胺受体类别的药理学关系的定量测定可能表明与2类（OA2A和OA2B）受体具有最大的同源性。因此，神经元章鱼胺受体应命名为3类受体（OA3）。利用拮抗剂建立了一种新的、简单的章鱼胺受体分类方案，该方案能够对新的受体类别进行分类。
